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I have lost two brothers to Alzheimer's so this is not an academic exercise to me. I agree that the assumption of amyloid being the single problem has wasted time and starved competing avenues of research. There have been others like Dr. Dale Bredesen that have for a long time has advocated other research. Does he have the right answer? Hard to tell because funding outside of plaques is hard to come by. I don't see the problem as an accidental selfish emperor that once replaced the system will heal. There is only one approach because there is only one major source of funding, the federal government. We have a monopoly by design and that determines how much of our health care is run. That a monopoly might be myopic should not come as a surprise. Sixty years ago the US medical system was more decentralized and considerably less monopolistic.

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