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On the question of former Wegovy patients putting the weight back on after ceasing their weekly injections, Dr. Michael Miedema, MD, MPH of the Minneapolis Heart Institute Foundation has looked at all the trial data, and uses the drugs in his clinical practice at Allina Health, the best health system in our market, in my experience.

Avoid the N=1 approach to making a difficult decision. In his clinical practice, he says that the split between patients who regain the weight and those who keep it off is about fifty-fifty. Another doctor's practice could show 100% regaining weight. It's just a sampling issue.

He also makes it clear that while these drugs are effective for a variety of patients, the best, largest population, longitudinal study on factors which help cardiovascular health and contribute to a better quality of life is The Framingham Study, which is widely available in many different forms. Framingham says, among other things, that a healthy diet (something akin to the Mediterranean diet) and moderate activity are among the best tools in keeping off the weight losses. We are in charge of our lifestyles and we have all the tools to manage our health and quality of life. Wegovy is a tool in the arsenal for many, but it is not a magic potion.

I highly recommend Dr. Miedema's presentation which is on the Minneapolis Heart Institute Foundation's You Tube Channel. Be forewarned: he speaks very rapidly. Have a recording device nearby, or if like me, you are good with a kinds of shorthand, keep a pad and pencil nearby. Between Drs. Miedema and Korner, you'll have all the real, undiluted, clinically relevant information you need.

https://www.youtube.com/watch?v=uhzftS5iw-U

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